Services

Equipment

• Agilent 1100 series

Applications

• Quantification of drug molecules in biological fluids
• Analysis of pharmaceutical preparations

Equipment

UHPLC – LTQ Orbitrap Velos, Thermo Scientific

Characteristics

• Ultra High Pressure Liquid Chromatography Mass Spectrometer
  Mass Accuracy  and  Ultra High Resolution 
• The LTQ Orbitrap Velos combines the proven mass accuracy and ultra-high resolution of the Orbitrap mass analyzer with the increased sensitivity and improved cycle time of the LTQ Velos to deliver high-performance
• Hybrid FT Mass Spectrometer.
• Accela LC System
• Heated Electrospray Ionization Probe (H- ESI II Probe)
• APCI Probe
• Unique dual-pressure trap technology
• New higher-energy collisional dissociation (HCD) cell
• Orbitrap mass analyzer

Applications

• Discovery and development of drugs • Metabolics

Equipment

HPLC-LCQ Fleet / Thermo Scientific

Characteristics

• Surveyor LC System
  Ion MAX ESI probe
  APCI Probe for the Ion Max Source
  Automatic Gain Control (AGC)
  Normalized Collision Energy
  Fast polarity switching 
• High Pressure Liquid Chromatography Mass Spectrometer
  The LCQ Fleet Ion Trap Mass Spectrometer delivers rich information for routine analysis of complex samples while providing excellent full-scan sensitivity, ruggedness and reliability.

Applicatons

• Analysis of natural products
• Impurity analysis
• Analytical applications

Equipment:

High Performance Liquid Chromatography System (HPLC RI / Diode Array – DAD) by Shimadzu [Shimadzu chromatography system, RID-10A / SPD-M40 detectors (Shimadzu Corp., Duisburg, Germany)].

Applications:

• Qualitative and quantitative determination of chemical composition of plant extracts
• Qualitative and quantitative determination of carbohydrates and organic acids (short chain fatty acids) in biological samples (microbial cultures, food, etc.)

Equipment

Kruss Optronics P3000

Characteristics

• The polarimeter is automatic and digital.
• Ensures measurement accuracy ± 0.01 °.
• Performs measurements in time ≤ 1.1 s.
• Has a measuring range in units of angle [°, ° Z] from ± 90 ° to ± 259 ° Z with a resolution of ± 0.01 ° Z.
• It has an accuracy better than ± 0.02˚ Z throughout the measuring range. • It has a repeatability of 0.01o, 0.01 ° Z.
• It has an LED light source with a filter.
• It has a sensitivity of 0.1% (OD3).

Applications

• Measurement of the optical angle of rotation of chiral joints

Equipment A

NMR 600 MHz Varian Spectrometer

Characteristics 

 Magnet
14.1 Tesla 54 mm bore Varian Superconducting Magnet

• Console:
  DIRECT DRIVE ARCHITECTURE INCLUDING POWER PC AND XILINX FPGA.
• Provides total pulse programming control and delivers precisely timed RF events.
• Complete waveform shaping capability.
• 3 RF Channels
• Channel 1 is highband, with 1H/19F observe, spinlock and decouple capability (550-600 MHz, 50W)
• Channels 2 & 3 have broadband observe, spinlock and decouple capability (18-245 MHz, 300 W)
• Performa IV Pulsed Field Gradient Module
• Protune Accessory
• Variable Temperature unit (-150C to +250C, with 0.1C resolution)
• Probes:
  1H{13C/15N} 5mm PFG Automatable Triple Resonance
  •  1 H{15N- 31P} 5 mm PFG AutoX Indirect Detect 600
  •  1 H-19F/15N- 31P 5mm PFG AutoX DB600
  •  4mm Nanoprobe (gHX 8 15W- 31P[1H] )
  Host computer: Dell 380N PC, Red Hat Linux
  Software: VNMRJ 2.2C

Applications

• Characterization of the structure of organic compounds
• DOSY experiments for separation of mixture components

• Triple coordination experiments of chemical compounds and biomolecules.

Equipment B

Spectrometer NMR 300 MHz Varian

Characteristics

Magnet:
7 Tesla 52 mm bore Oxford Magnet

Console:
DIRECT DRIVE ARCHITECTURE INCLUDING POWER PC AND XILINX FPGA.

• Provides total pulse programming control and delivers precisely timed RF events. Complete waveform shaping capability.
• Channel 1 is highband, with 1H/19F observe, spinlock and decouple capability (200-300 MHz, 50W)
• Channels 2 has broadband observe, spinlock and decouple capability (12-220 MHz, 300 W and 220-245 MHz, 150 W)
• Performa I Pulsed Field Gradient Module
• Carousel autosampler for 9 samples
• Variable Temperature unit (-15oC to +25oC, with 0.1oC resolution)

Probes: 1 H/19F/31P/13C 5mm PFG AutoSwitchable
Host computer: Dell 380N PC, Red Hat Linux 
Software: VNMRJ 2.2C 

Applications

• Single and double coordination studies for the complete characterization of the structure of organic compounds.

used to determine the structure and to analyze the purity of chemical compounds

Equipment

Agilent 500 MHz

Characteristics

• Fluid analysis
• It can measure many nuclei (1H, 13C, 31P, 11B and 15N) and conduct 2D NMRs experiments at different temperatures.

Applications

• Pharmaceutical Industry
• Industry of food, perfumes, paints, polymers –
• Analysis of chemical compounds, perfumes, agrochemicals, drugs, detergents, natural products, polymers

Equipment

Agilent Gas Chromatography / Mass Spectrometry System [6890N GC, 5973 NetworkedMS MSD (Agilent Technologies, Santa Clara, CA, USA)]

Applications:

• Qualitative and quantitative determination of chemical composition of essential oils and plant extracts (volatolomics)
• Qualitative and quantitative determination of microbial metabolites (metabolomics)

Used to analyze the purity of chemical compounds

Equipment

GC-2030 Shimadzu

Characteristics

Features SPL-2030 split / splitless sample injection system and FID-2030 flame ionization detector (FID)

Applications

• Pharmaceutical Industry
• Food, perfume, beverage industry
• Analysis of natural products